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Metabolic changes induced by human growth hormone.

E Jover, C Paradinas, R Velasco

    Journal of Medicine
    |January 1, 1977
    PubMed
    Summary

    Human growth hormone inhibits fat breakdown and sugar production in humans. It also boosts an enzyme crucial for cholesterol metabolism and lowers blood amino acid levels.

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    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Human growth hormone (hGH) plays a vital role in metabolic regulation.
    • Understanding the specific metabolic effects of purified hGH in humans is crucial for therapeutic applications.

    Purpose of the Study:

    • To investigate the metabolic effects of purified human growth hormone in human subjects.
    • To elucidate the impact of hGH on lipolysis, glycolysis, and lipid metabolism.

    Main Methods:

    • Administration of purified human growth hormone to human subjects.
    • Measurement of lipolytic and glycolytic activity.
    • Assay of lecithin-cholesterol-acyl-transferase (LCAT) activity.
    • Analysis of blood amino acid levels.

    Main Results:

    • Purified human growth hormone demonstrated a significant anti-lipolytic effect, inhibiting fat breakdown.
    • Glycolysis, the breakdown of glucose, was observed to be inhibited by hGH.
    • The activity of lecithin-cholesterol-acyl-transferase (LCAT), an enzyme vital for cholesterol metabolism, was stimulated.
    • A decrease in the blood levels of certain amino acids was noted following hGH administration.

    Conclusions:

    • Purified human growth hormone exerts multifaceted metabolic effects in humans.
    • hGH influences lipid and carbohydrate metabolism, as well as amino acid homeostasis.
    • These findings contribute to the understanding of hGH's physiological actions and potential clinical implications.

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