Related Experiment Video
Updated: Mar 20, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
The Pediatric Sleep Clinical Global Impressions Scale-A New Tool to Measure Pediatric Insomnia in Autism Spectrum
Beth A Malow1, Heidi V Connolly, Shelly K Weiss
1*Sleep Disorders Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN; †Department of Pediatrics, University of Rochester, Rochester, NY; ‡Department of Neurology, Hospital for Sick Children, University of Toronto, Toronto, ON; §Department of Pediatrics, University of Colorado Denver, Aurora, CO; ‖Biostatistics Center, Massachusetts General Hospital, Boston, MA.
Insights
A new clinician-rated scale shows promise for assessing pediatric insomnia in children with autism spectrum disorder (ASD). This tool complements objective and parent-reported measures, offering valuable insights into sleep difficulties.
Area of Science:
- Pediatric Sleep Medicine
- Autism Spectrum Disorders (ASD) Research
- Clinical Outcome Measurement
Background:
- Insomnia is a common challenge for children with autism spectrum disorder (ASD), impacting their development and family life.
- Existing assessment tools for pediatric insomnia include objective measures and parent-based questionnaires, but a clinician-centered perspective is also valuable.
Purpose of the Study:
- To pilot a novel clinician-based outcome measure for evaluating insomnia in children with ASD.
- To assess if the new measure provides information complementary to existing objective and parent-reported assessments.
Main Methods:
- Development and refinement of the Pediatric Sleep Clinical Global Impressions Scale (CGI) with expert input.
- Pilot testing of the Pediatric Sleep CGI in a 12-week randomized trial involving children with ASD, utilizing clinician assessments, parent questionnaires (CSHQ), and actigraphy.
Main Results:
- The Pediatric Sleep CGI demonstrated significant correlations with parent-reported sleep onset delay and night wakings.
- Clinician-rated sleep onset delay scores correlated well with objective actigraphy data.
- The overall clinician-rated scale indicated improvement in sleep with the intervention.
Conclusions:
- The Pediatric Sleep CGI shows potential as a reliable tool for measuring clinician-rated outcomes in pediatric insomnia among children with ASD.
- Further research with larger sample sizes is needed to confirm its reliability, validity, and applicability to diverse pediatric insomnia populations.
Objective:
To pilot a clinician-based outcome measure that provides complementary information to objective measures and parent-based questionnaires for insomnia in children with autism spectrum disorders (ASD).
Method:
The authors developed a Pediatric Sleep Clinical Global Impressions Scale (CGI). Questions included (1) the child's ability to fall asleep and remain sleeping independently (i.e., apart from parents); (2) bedtime resistance; (3) sleep onset delay; (4) night awakening; (5) parental satisfaction with their child's current sleep patterns; (6) family functioning as affected by their child's current sleep patterns; and (7) clinician's overall concern with the child's sleep. After refining the instrument through the evaluation of vignettes by ASD and sleep experts, the authors piloted the Pediatric Sleep CGI in a 12-week randomized trial of iron supplementation in children with ASD. Clinicians completed Pediatric Sleep CGIs and structured sleep histories, parents completed the Children's Sleep Habits Questionnaire (CSHQ), and children wore actigraphy watches.
Results:
In repeated measures models, the Pediatric Sleep CGI and CSHQ were correlated for sleep onset delay (r = .66, p < .001), night wakings (r = .40, p < .001), and total score (r = .29, p < .001). The CGI-S sleep onset delay and actigraphy sleep onset delay scores (r = .75, p = .0095) were also correlated. The overall CGI-S showed improvement with therapy (p = .047).
Conclusion:
The Pediatric Sleep CGI shows promise in measuring clinician-rated outcomes in pediatric insomnia in children with ASD. Larger samples will be necessary to examine reliability, validity, and measure to change, as well as applicability to other populations with pediatric insomnia.
Related Concept Videos
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Insomnia
Multiple factors contribute...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Management of Insomnia
REM Sleep Behavior Disorder
RBD is significantly associated with...
Nightmares and Night Terrors
Nightmares...

