Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ABCA7 Mutation in Behavioral Variant of Frontotemporal Dementia: A Case Report.

Case reports in neurology·2026
Same author

Precision, patient satisfaction and impression time with complete-arch digital implant impression with intraoral scanning, dental photogrammetry and conventional impressions: An experimental clinical study.

International journal of oral implantology (Berlin, Germany)·2026
Same author

From Preservation to Regeneration: Stem Cell-Derived Therapies in Machine-Perfused Kidney Transplants - A systematic Review and Meta-analysis.

Kidney & blood pressure research·2026
Same author

Heterogeneity of baseline immune activation and SARS-CoV-2 vaccine responses in people with HIV: a multicenter prospective study.

AIDS (London, England)·2026
Same author

Sleep arousals are associated with the polygenic risk for developing Alzheimer's disease and with cognitive change in healthy late middle-aged individuals.

Sleep·2026
Same author

Two-year clinical comparison of direct and indirect composite restorations in severely damaged molars: A split-mouth randomized clinical study.

Journal of dentistry·2026

Related Experiment Video

Updated: Mar 20, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.9K

Multimodal evoked potentials for functional quantification and prognosis in multiple sclerosis.

Xavier Giffroy1,2, Nathalie Maes3, Adelin Albert3

  • 1Department of Neurology, University Hospital of Liege, Rue Grandfosse 31-33, 4130, Esneux, Belgium. xgiffroy@chu.ulg.ac.be.

BMC Neurology
|June 2, 2016
PubMed
Summary
This summary is machine-generated.

Multimodal evoked potentials (EP) can predict multiple sclerosis (MS) disability progression. A global EP score helps identify MS patients at high risk of worsening, serving as a complementary prognostic tool alongside MRI.

Keywords:
DisabilityEvoked potentialsMultiple sclerosisPrognosis

More Related Videos

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

9.9K
Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:13

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

834

Related Experiment Videos

Last Updated: Mar 20, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.9K
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

9.9K
Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography
12:13

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

834

Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Lack of functional biomarkers to predict multiple sclerosis (MS) disability progression.
  • Need for tools to monitor disease course and identify high-risk patients.

Purpose of the Study:

  • Evaluate multimodal evoked potentials (EP) for monitoring MS disease course.
  • Identify patients with unfavorable evolution using EP.

Main Methods:

  • Assessed 100 MS patients using visual, somatosensory, and motor EP at baseline and 6-year follow-up.
  • Correlated EP scores with Expanded Disability Status Scale (EDSS) using Spearman correlation.
  • Used logistic regression to assess predictive value of baseline EP data for EDSS outcomes.

Main Results:

  • Baseline global EP score and EDSS significantly predicted EDSS progression over 6 years.
  • Global EP score independently predicted annual EDSS progression rate and risk of disability.
  • A Global EP Score cutoff of 17/30 identified high-risk patients with 70% positive predictive value.

Conclusions:

  • Electrophysiology, specifically multimodal evoked potentials, can serve as a complementary prognostic tool in MS.
  • EPs offer a valuable addition to MRI for predicting MS patient outcomes.