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Updated: Mar 20, 2026

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

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Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and

Ami Patel1, Harika Sabbineni2, Andrea Clarke1

  • 1Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, United States.

Life Sciences
|June 2, 2016
PubMed

Insights

Src-family kinases (SFKs) drive cancer progression by promoting cell motility, invasion, and metastasis. Targeting SFKs, like c-Src, offers a promising strategy for cancer therapy and vascular normalization.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Src-family kinases (SFKs) are intracellular non-receptor tyrosine kinases implicated in oncogenesis.
  • SFKs promote tumor cell motility, proliferation, invasion, and metastasis.
  • Novel roles in epithelial-to-mesenchymal transition (EMT) and tumor microenvironment modulation are emerging.

Purpose of the Study:

  • To review the novel roles of SFKs, particularly c-Src, in cancer progression.
  • To discuss the impact of SFKs on EMT, tumor microenvironment, and metastasis.
  • To explore the therapeutic potential of Src inhibitors in cancer treatment and vascular normalization.

Main Methods:

  • Literature review of studies on SFKs in cancer.
  • Analysis of SFK involvement in EMT, angiogenesis, and metastasis.
  • Discussion of clinical relevance of Src inhibitors.

Main Results:

  • SFKs, especially c-Src, play critical roles in mediating EMT.
  • SFKs modulate the tumor endothelial barrier, facilitating cancer cell invasion and metastasis.
  • Src inhibition shows potential for vascular normalization and as a cancer therapy.

Conclusions:

  • SFKs are key regulators of cancer cell invasion and metastasis through EMT and microenvironment interactions.
  • Targeting SFKs, including c-Src, presents a viable therapeutic strategy for various cancers.
  • Src inhibitors may offer dual benefits in normalizing tumor vasculature and inhibiting cancer progression.
Keywords:
EMTMetastasisMicroinvasionSrcVascular permeability

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