Intraocular pressure and ocular biometric parameters changes in migraine

Area of Science:

• Ophthalmology
• Neurology

Background:

• Migraine is a common neurological disorder.
• Ocular parameters may be affected during migraine attacks.
• The AL-Scan optical biometer offers new assessment capabilities.

Purpose of the Study:

• To evaluate intraocular pressure (IOP) and ocular biometrics in migraine patients during acute attacks.
• To compare these measurements with migraine patients in painless periods and healthy controls.
• To utilize the AL-Scan optical biometer for precise measurements.

Main Methods:

• Prospective, case-control study design.
• Inclusion of 40 migraine patients and 40 healthy controls.
• Measurement of axial length, corneal curvature, anterior chamber depth, central corneal thickness, and pupil size using AL-Scan.
• Standardized measurement timing (10:00-12:00) to control for diurnal variations.

Main Results:

• No statistically significant differences in intraocular pressure were observed across the three groups (migraine attack, painless period, controls).
• Ocular biometric parameters, including axial length and corneal measurements, did not significantly vary during acute migraine attacks.
• Individual measurements for IOP were: migraine attack (15.07 mmHg), painless period (14.10 mmHg), and controls (15.73 ± 0.81 mmHg).

Conclusions:

• The study did not find a direct association between acute migraine attacks and significant changes in intraocular pressure or ocular biometrics.
• Further research is warranted to investigate the complex etiopathologic relationship between migraine and ocular parameters.
• The role of the AL-Scan biometer in future ophthalmic research is highlighted.