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TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

Kazunori Hashimoto1, Alicia N Simmons1, Rie Kajino-Sakamoto1

  • 1Department of Biological Sciences, North Carolina State University , Raleigh, North Carolina.

Antioxidants & Redox Signaling
|June 2, 2016
PubMed
Summary

TGF-β-activated kinase 1 (TAK1) regulates the antioxidant factor Nrf2 by controlling p62/SQSTM1-dependent Keap1 degradation. This mechanism maintains Nrf2 levels and antioxidant defense in the intestinal epithelium.

Keywords:
Keap1Nrf2TAK1intestinep62/SQSTM

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