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Updated: Mar 20, 2026
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
Published on: September 11, 2012
AOM/DSS Model of Colitis-Associated Cancer
Bobak Parang1,2, Caitlyn W Barrett3, Christopher S Williams4,5,6,7
1Department of Medicine, Division of Gastroenterology, Vanderbilt University, 1065D MRB-IV, B2215 Garland Avenue, Nashville, TN, 37232, USA.
Abstract:
Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.
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