Related Experiment Video
Updated: Sep 29, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
[Primary Synovial Sarcoma in the Anterior Mediastinum;Report of a Case]
Naoki Yanagawa1, Satoshi Shiono, Masato Katahira
1Department of Diagnostic Pathology, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Abstract:
We report a rare case of synovial sarcoma in the anterior mediastinum. A 43-year-old man consulted our hospital with a complaint of dyspnea and chest discomfort. Chest computed tomography revealed an anterior mediastinal mass. Small open biopsy was performed, and the pathological examination revealed spindle-shaped cells with severe atypia. Tumor resection was performed. On pathology, fascicular and storiform patterns of spindle-shaped cells with severe atypia were noted. The tumor cells were positive for cytokeratin 7, vimentin, Bcl -2 and CD99, and the amplification of SYT-SSX fusion gene was also found. Therefore it was diagnosed as a synovial sarcoma.

