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Malignant pleural effusion: from bench to bedside

Ioannis Psallidas1, Ioannis Kalomenidis2, Jose M Porcel3

  • 1Oxford Respiratory Trials Unit, Oxford Centre for Respiratory Medicine, Oxford University Hospitals Trust, Oxford, UK ioannis.psallidas@ndm.ox.ac.uk.

European Respiratory Review : an Official Journal of the European Respiratory Society
|June 2, 2016
PubMed

Insights

Malignant pleural effusion (MPE) management has advanced, improving patient care from palliative to ambulatory treatments. This overview covers recent MPE diagnostics, pathophysiology, and future research directions.

Area of Science:

  • Oncology
  • Pulmonology
  • Thoracic Medicine

Background:

  • Malignant pleural effusion (MPE) is a serious condition impacting quality of life, morbidity, and mortality.
  • Rising incidence and healthcare costs associated with MPE necessitate improved management strategies.
  • Current MPE management is primarily palliative, with limited median survival (3-12 months).

Purpose of the Study:

  • To provide a comprehensive overview of current advances in malignant pleural effusion (MPE) research and clinical practice.
  • To highlight recent progress in MPE pathophysiology, diagnostics, imaging, and treatment.
  • To identify unanswered questions and suggest future research directions in the MPE field.

Main Methods:

  • Review of recent literature on malignant pleural effusion (MPE).
  • Synthesis of current knowledge on MPE pathophysiology, diagnostics, and management.
  • Identification of emerging trends and future research needs in MPE.

Main Results:

  • Significant progress has been made in understanding MPE pathophysiology, diagnostics, and management over the last decade.
  • Patient treatment has shifted towards ambulatory care, with advancements in genotyping and phenotyping.
  • Formerly bed-ridden patients can now be managed on an outpatient basis.

Conclusions:

  • Advances in MPE research have led to improved diagnostic and therapeutic approaches.
  • Future research should focus on addressing current clinical practice gaps and further optimizing MPE management.
  • The field is moving towards more personalized and less invasive treatments for malignant pleural effusion.

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