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Updated: Mar 20, 2026

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Published on: May 1, 2020
Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism
Szymon J Ciesielski1, Elizabeth A Craig2
1Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI, 53706, USA.
Abstract:
Though toxic in excess, iron is vital for life. Thus, its use in all cells is tightly regulated. Analysis of Saccharomyces cerevisiae, which has been used extensively as a model system, has revealed layers of regulation of cellular iron trafficking and utilization. This regulation is based on the availability of both elemental iron and functionality of the Fe-S cluster biogenesis system. Here, we discuss a possible "first responder" regulatory mechanism centered on the stability of the scaffold protein on which Fe-S clusters are built.
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