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Castration increases striatal D-2 dopamine receptors in mid-life rats
H Watanabe1, K Matsumoto, L Imamura
1Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Japanese Journal of Pharmacology
|May 1, 1989
Abstract:
Effect of castration on [3H]-spiperone binding in the striatum of mid-life/mature rats was investigated. Four weeks after castration an increase in D-2 dopamine receptors was noted, and this was partially reduced by testosterone. These results suggest that testosterone may regulate striatal D-2 dopamine receptors in an age-dependent manner.