[Study of the blood coagulation and fibrinolysis systems in evaluating the activity of glomerulonephritis]

Certain parameters of blood coagulation and fibrinolysis were studied in 84 patients suffering from different variants of chronic glomerulonephritis. The disease is characterized by various conditions of the coagulation system, and acceleration of the initial stages of coagulation; the most typical are disturbances of thrombin inactivation. Simultaneous accumulation in the blood of products of degradation of fibrin and monomeric fibrin complexes is observed. The degree of manifestation of changes in blood coagulation and fibrinolytic systems corresponds to disease activity. The tests used are more sensitive than the traditional clinicolaboratory tests and reveal not only manifested by also latent disease activity.