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Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic

Mikko Jalanko1, Mika Tarkiainen2, Petri Sipola2

  • 1a Department of Cardiology , Helsinki University Hospital, Heart and Lung Center , Helsinki , Finland.

Annals of Medicine
|June 2, 2016
PubMed

Insights

Speckle tracking echocardiography

Area of Science:

  • Cardiology
  • Medical Imaging
  • Electrophysiology

Background:

  • Hypertrophic cardiomyopathy (HCM) poses a risk for sudden cardiac death.
  • Identifying HCM patients at risk for malignant ventricular arrhythmias is crucial.
  • Novel imaging techniques are needed to assess this risk.

Purpose of the Study:

  • To evaluate mechanical dispersion (MD) using 2D strain echocardiography (2DSE).
  • To compare MD with other parameters in differentiating HCM patients with and without nonsustained ventricular tachycardia (NSVT).
  • To assess the diagnostic value of MD in predicting NSVT in HCM.

Main Methods:

  • 31 HCM patients (MYBPC3-Q1061X mutation) and 20 controls underwent 2DSE and cardiac magnetic resonance imaging (CMRI).
  • 24-h ambulatory ECG monitoring was used to detect NSVT.
  • Mechanical dispersion (MD) was measured using speckle tracking 2D strain echocardiography.

Main Results:

  • NSVT was present in 35% of HCM patients.
  • MD was significantly higher in HCM patients with NSVT (93 ms) compared to those without (50 ms) and controls (41 ms).
  • MD was the sole independent predictor of NSVT (OR 1.60) and showed the best differentiation (AUC 0.81).

Conclusions:

  • Increased mechanical dispersion is linked to NSVT in HCM patients.
  • 2DSE-derived MD is a valuable tool for identifying HCM patients at risk for NSVT.
  • This imaging method aids in stratifying risk for ventricular arrhythmias in HCM.
Abstract

Keywords:
Arrhythmiacardiac magnetic resonanceechocardiographyrisk assessmentspeckle trackingsudden cardiac death

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