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Statin-treated patients with aneurysmal subarachnoid haemorrhage: a meta-analysis

R-L Zhu1, Z-J Chen, S Li

  • 1Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. lilixin2@hotmail.com.

European Review for Medical and Pharmacological Sciences
|June 2, 2016
PubMed

Insights

Statins may reduce cerebral vasospasm after subarachnoid hemorrhage (SAH). However, this meta-analysis found no significant benefit of statins for preventing delayed ischemic neurological deficit (DIND), mortality, or poor neurological outcomes in SAH patients.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Aneurysmal subarachnoid hemorrhage (SAH) frequently leads to cerebral vasospasm, delayed ischemic neurological deficit (DIND), and poor neurological outcomes.
  • The efficacy of statin therapy in mitigating these adverse events following SAH has not been thoroughly evaluated.

Purpose of the Study:

  • To comprehensively assess the effects of statin treatment on cerebral vasospasm, DIND, mortality, and neurological outcomes in patients with aneurysmal SAH.

Main Methods:

  • A systematic literature search was performed across major databases (PubMed, EMBASE, ScienceDirect, Web of Science) up to March 2015.
  • Data from nine RCTs and three observational studies, totaling 1957 patients, were extracted and analyzed using fixed or random effects models.

Main Results:

  • Statin treatment showed a potential reduction in the incidence of cerebral vasospasm (RR: 0.77, 95% CI: 0.66-0.89, p = 0.0006).
  • No significant association was found between statin use and decreased occurrence of DIND (RR: 0.81, 95% CI: 0.66-1.00, p = 0.05), mortality (RR: 0.90, 95% CI: 0.69-1.18, p = 0.46), or poor neurological outcome (RR: 1.02, 95% CI: 0.86-1.20, p = 0.84).

Conclusions:

  • This meta-analysis suggests that statins may decrease the occurrence of cerebral vasospasm in patients with aneurysmal SAH.
  • However, current evidence does not support a beneficial effect of statins on DIND, mortality, or poor neurological outcomes in this patient population.
Abstract

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