Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K

[OPTICAL BIOPSY FOR DIAGNOSIS OF ESOPHAGEAL MUCOSAL CHANGES IN CHILDREN]

A A Shavrov, G V Volynets, A A Shavrov

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |June 3, 2016
    PubMed

    Insights

    Confocal laser endomicroscopy (CLE) shows high sensitivity and specificity in diagnosing pediatric upper gastrointestinal conditions. This advanced imaging technique aids in the early detection of esophagitis, metaplasia, and polyps in children.

    Area of Science:

    • Pediatric Gastroenterology
    • Gastrointestinal Endoscopy
    • Optical Diagnostics

    Context:

    • Upper gastrointestinal tract mucosal changes in children require accurate diagnostic methods.
    • Conventional endoscopy supplemented with confocal laser endomicroscopy (CLE) offers advanced visualization.
    • Evaluating CLE's diagnostic value in pediatric patients is crucial for improving patient outcomes.

    Purpose:

    • To analyze the diagnostic value of confocal laser endomicroscopy (CLE) in identifying upper gastrointestinal mucosal abnormalities in pediatric patients.
    • To compare the diagnostic accuracy of CLE-based optical biopsy with traditional histology.

    Summary:

    • A study involving 116 children (ages 3-18) compared probe-based CLE with standard histology for diagnosing esophageal conditions.
    • CLE demonstrated high sensitivity and specificity for esophagitis (88.8%/88.3%), metaplasia (92.3%/95.3%), and polyps (92.4%/95.2%).
    • Strong correlations were observed between CLE findings and histological results (Spearman's correlation 0.79-0.95, p<0.001).

    Impact:

    • Confocal laser endomicroscopy (CLE) shows significant potential as a leading diagnostic tool in pediatric gastroenterology.
    • CLE enables real-time, in-situ cellular-level mucosal examination during endoscopy.
    • This technology can assist endoscopists in establishing timely and accurate diagnoses for pediatric gastrointestinal diseases.
    Abstract

    More Related Videos

    Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation14:21

    Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

    Published on: January 22, 2013

    14.7K
    Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis03:23

    Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

    Published on: May 10, 2024

    1.5K

    Related Concept Videos

    Barrett Esophagus-II: Clinical Manifestations and Management01:21

    Barrett Esophagus-II: Clinical Manifestations and Management

    Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
    To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
    1.4K
    Barrett Esophagus-I: Introduction01:21

    Barrett Esophagus-I: Introduction

    Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
    This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
    1.2K
    Esophageal Strictures-II: Clinical Features and Management01:26

    Esophageal Strictures-II: Clinical Features and Management

    Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
    Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
    854
    Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

    Endoscopic Studies I: Bronchoscopy and Thoracoscopy

    Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
    Bronchoscopy
    Description
    Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
    877
    Esophagus01:24

    Esophagus

    The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
    The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
    4.4K
    Esophageal Strictures-I: Introduction01:30

    Esophageal Strictures-I: Introduction

    Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
    Etiology
    The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
    1.1K