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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Related Experiment Video

Updated: Jan 20, 2026

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
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Degenerative cervical myelopathy.

So Kato1, Michael Fehlings2,3,4

  • 1Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Current Reviews in Musculoskeletal Medicine
|June 3, 2016
PubMed
Summary
This summary is machine-generated.

Degenerative cervical myelopathy (DCM) is a progressive spinal cord condition. Early surgical intervention is recommended for most DCM cases to achieve optimal outcomes, with ongoing research into adjunctive therapies.

Keywords:
Adjuvant therapyApproachDegenerative cervical myelopathyNon-surgical treatmentPrognosisSurgical treatment

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Area of Science:

  • Neurosurgery
  • Spinal Cord Medicine
  • Degenerative Diseases

Background:

  • Cervical myelopathy represents the leading cause of acquired spinal cord compromise.
  • Degenerative cervical myelopathy (DCM) is defined as symptomatic myelopathy linked to degenerative spinal changes.
  • DCM's progressive nature necessitates timely treatment decisions.

Purpose of the Study:

  • To introduce the concept and management principles of degenerative cervical myelopathy (DCM).
  • To outline current and emerging treatment strategies for DCM.
  • To emphasize the importance of timely intervention and risk assessment.

Main Methods:

  • Review of surgical interventions for DCM, including anterior discectomy and fusion (ACDF), anterior corpectomy and fusion (ACCF), arthroplasty, laminectomy, and laminoplasty.
  • Discussion of adjunctive therapies, such as Riluzole, evaluated in clinical trials (e.g., CSM-Protect RCT).
  • Emphasis on preoperative risk assessment and the role of sagittal alignment in surgical planning.

Main Results:

  • Surgical options for DCM are diverse, with specific indications for each procedure.
  • Riluzole shows promise for improving postoperative neurologic outcomes.
  • Preoperative risk assessment and sagittal alignment are crucial for prognostication and surgical success.

Conclusions:

  • Most cases of DCM, excluding the mildest, should be considered for surgical treatment to optimize outcomes.
  • Careful consideration of individual patient factors is essential when selecting surgical approaches.
  • Guidelines for DCM management are under development, highlighting the need for standardized care.