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Chromatin Position Affects Gene Expression02:35

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
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Cervical radiculopathy.

Sravisht Iyer1, Han Jo Kim2

  • 1Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA.

Current Reviews in Musculoskeletal Medicine
|June 3, 2016
PubMed
Summary
This summary is machine-generated.

Cervical radiculopathy, causing neck and arm pain, is common. This review covers its diagnosis, natural history, and management options, including conservative care and surgical interventions like ACDF, CDA, and PCF.

Keywords:
ACDFCervical disc arthroplastyCervical radiculopathyNon-operative managementPhysical examinationPosterior cervical foraminotomy

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Area of Science:

  • Neurology
  • Orthopedics
  • Neurosurgery

Background:

  • Cervical radiculopathy frequently presents as neck and arm pain.
  • Accurate diagnosis relies on patient history and physical examination findings.

Purpose of the Study:

  • To review the epidemiology and diagnosis of cervical radiculopathy.
  • To discuss differential diagnoses, natural history, and management options.
  • To analyze surgical outcomes for anterior cervical decompression and fusion (ACDF), cervical disc arthroplasty (CDA), and posterior cervical foraminotomy (PCF).

Main Methods:

  • Review of epidemiology, diagnostic criteria, and clinical presentation.
  • Discussion of differential diagnoses including peripheral nerve entrapment and shoulder pathology.
  • Analysis of conservative and operative management strategies and surgical outcomes.

Main Results:

  • Cervical radiculopathy diagnosis involves detailed history and physical exam.
  • Management includes conservative measures (physical therapy, injections) and surgery.
  • Surgical outcomes for ACDF, CDA, and PCF are presented.

Conclusions:

  • Cervical radiculopathy requires a thorough diagnostic approach.
  • Management strategies vary from conservative to surgical interventions.
  • Understanding surgical outcomes aids in treatment decisions for cervical radiculopathy.