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Impact of post-processing methods on apparent diffusion coefficient values.

Martin Georg Zeilinger1, Michael Lell1, Pascal Andreas Thomas Baltzer2

  • 1Institute of Diagnostic Radiology, University of Erlangen-Nuremberg, Maximiliansplatz 1, D-91054, Erlangen, Germany.

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Summary
This summary is machine-generated.

Post-processing methods significantly impact apparent diffusion coefficient (ADC) values in oncological imaging. Standardizing these methods is crucial for reproducible ADC measurements and reliable patient study comparisons.

Keywords:
ADCDWIMRIReproducibilityTumour

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Area of Science:

  • Radiology
  • Medical Imaging
  • Oncological Imaging

Background:

  • Apparent diffusion coefficient (ADC) is a key quantitative biomarker in oncological imaging.
  • ADC values are derived from raw diffusion-weighted imaging (DWI) data.
  • Various post-processing methods (PPMs) exist for ADC calculation.

Purpose of the Study:

  • To investigate the impact of different post-processing methods (PPMs) on final ADC values.
  • To determine if PPMs influence the quantitative biomarker in oncological imaging.
  • To assess the variability of ADC values based on PPM selection.

Main Methods:

  • Sixty-five lesions were analyzed using standardized whole-body DWI at 3T.
  • Four distinct PPMs (ADC_1-ADC_4) were applied to the same region of interest (ROI) coordinates.
  • Statistical analyses, including Wilcoxon signed-rank tests and calculation of coefficient of variation (CV), were performed.

Main Results:

  • Mean ADC values varied between PPMs, with a relative difference (∆) of 7.0%.
  • Variances were more pronounced at higher ADC values (∆ = 8.0%).
  • Significant differences (P ≤ 0.003) were found between all PPMs, with a mean CV of 7.2%.

Conclusions:

  • Post-processing methods significantly influence calculated ADC values.
  • The observed variability necessitates careful consideration when comparing ADC values across studies.
  • Standardization of PPM is recommended to ensure reproducible ADC measurements.