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The role of IL-37 in cancer
Vivi A Ding1, Ziwen Zhu2, Huaping Xiao3
1Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, USA.
Abstract:
Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis.
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