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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

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Biomaterials for Enhancing CNS Repair.

Teck Chuan Lim¹, Myron Spector^2,3

¹Institute of Bioengineering and Nanotechnology, Singapore, Singapore. tclim@ibn.a-star.edu.sg.

Translational Stroke Research

|June 3, 2016

Summary

Biomaterials are crucial for central nervous system (CNS) health, aiding tissue repair after injury or disease. This review explores their use in cell transplantation and drug delivery for CNS therapeutics.

Keywords:

Bioimaging Cell transplantation Drug and protein delivery Endogenous cells and molecules Glycomimetics Hydrogels Immunomodulation Matrix architecture Scaffolds Temporal control

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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

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Published on: October 1, 2020

Area of Science:

Neuroscience
Biomaterials Science
Regenerative Medicine

Background:

Central nervous system (CNS) health depends on neural cells and extracellular matrix organization.
Injury and disease disrupt CNS tissue function, necessitating therapeutic interventions.
Biomaterials offer promising solutions for restoring CNS structure and function.

Purpose of the Study:

To review the role of biomaterials in CNS therapeutic strategies.
To highlight applications in cell transplantation and drug/protein delivery for the CNS.
To discuss future advances in biomaterial design for CNS applications.

Main Methods:

Literature review of biomaterial applications in CNS research.
Analysis of therapeutic strategies involving cell transplantation and drug delivery.
Examination of current and emerging biomaterial designs.

Main Results:

Biomaterials are effective in supporting cell transplantation and controlled release of therapeutics in the CNS.
Advances in biomaterial design offer enhanced biocompatibility and functionality.
These materials show potential for restoring tissue function and promoting neural repair.

Conclusions:

Biomaterials are essential tools for CNS repair and regeneration.
Innovations in biomaterial science will drive future CNS therapeutic development.
Translational applications of advanced biomaterials promise significant benefits for CNS disorders.