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Related Concept Videos

Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Related Experiment Video

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Formation of Dispersible Taohong Siwu Tablets
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Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping.

Jonas Buck1,2, Jörg Huwyler2, Peter Kühl3

  • 1Pharmaceutical Research and Development, F. Hoffmann-La Roche, Grenzacherstr. 124, CH-4070, Basel, Switzerland.

Pharmaceutical Research
|June 3, 2016
PubMed
Summary

Developing pediatric dispersible tablets requires careful selection of viscosity enhancers and superdisintegrants. Optimized formulations achieve rapid disintegration (<30s) and good mouthfeel, meeting children's specific needs.

Keywords:
disintegrationdispersible tabletfluid bedpediatrictexture analyzer

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Area of Science:

  • Pharmaceutical Sciences
  • Formulation Development
  • Pediatric Drug Delivery

Background:

  • Designing pediatric solid dosage forms presents unique challenges, including varied dosing requirements.
  • A modular formulation strategy enables rapid prototyping for pediatric tablets.

Purpose of the Study:

  • To investigate different tablet compositions and characteristics for pediatric dispersible tablets.
  • To develop customized analytical methods for evaluating pediatric tablet properties.

Main Methods:

  • Fluid bed granules were blended with extragranular components and compressed into tablets.
  • Disintegration behavior was assessed using a Texture Analyzer and Tensiometer.
  • Methods for determining disintegration time and water uptake were established.

Main Results:

  • Twenty-two tablet formulations were analyzed for disintegration time, hardness, friability, and viscosity.
  • Multivariate data analysis highlighted the significant impact of viscosity enhancers on tablet disintegration.
  • An optimized formulation achieved a disintegration time of 24 seconds.

Conclusions:

  • Novel methods provide enhanced insights into dispersible tablet disintegration beyond pharmacopoeia standards.
  • Critical factors for pediatric tablet development include selecting appropriate viscosity enhancers and superdisintegrants.
  • Achieving rapid disintegration (<30s) and pleasant mouthfeel is key for successful pediatric formulations.