Related Experiment Video
Updated: Mar 20, 2026
08:00
Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
Published on: June 24, 2019
8.8K
The cross-talk between enterocytes and intraepithelial lymphocytes
Serena Vitale1, Stefania Picascia1, Carmen Gianfrani2
1Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, 80131, Naples, Italy.
Molecular and Cellular Pediatrics
|June 3, 2016
Summary
The gut lining
Area of Science:
- Immunology
- Gastroenterology
- Cell Biology
Background:
- The gut mucosa constantly encounters food and microbial antigens.
- Enterocytes and intraepithelial lymphocytes are crucial for intestinal integrity and defense.
- Disrupted communication between these cells can lead to immune disorders.
Purpose of the Study:
- To review recent studies on the pathophysiology of enterocyte and intraepithelial T cell cross-talk.
- To highlight the importance of this interaction for intestinal integrity and homeostasis.
- To discuss the role of this cross-talk in celiac disease.
Main Methods:
- Literature review of recent studies.
- Analysis of the pathophysiology of cell-cell interactions in the gut.
- Examination of immune responses in celiac disease models.
Main Results:
- Enterocytes form a physical barrier and sample luminal antigens.
- Intraepithelial lymphocytes are key in controlling pathogen entry.
- Gluten exposure in celiac disease triggers interleukin-15 production and lymphocyte activation, altering mucosal architecture.
Conclusions:
- The cross-talk between enterocytes and intraepithelial T cells is vital for maintaining intestinal integrity and homeostasis.
- Alterations in this communication are implicated in intestinal immune disorders like celiac disease.
- Understanding this interaction is crucial for developing therapeutic strategies.
Related Concept Videos
01:23Renewal of Intestinal Stem Cells
3.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.5K
01:18Lymphoid Cells and Tissues
3.7K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.7K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.8K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.8K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
01:15Transcytosis of IgG
4.5K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.5K
01:15Secondary Lymphoid Organs
10.1K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.1K