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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
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Stem Cells for Neonatal Brain Disorders.

So Yoon Ahn1, Yun Sil Chang, Won Soon Park

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Neonatology
|June 3, 2016
PubMed
Summary

Stem cell therapy shows promise for treating neonatal brain injury from intraventricular hemorrhage and hypoxic-ischemic encephalopathy. This review focuses on preclinical data and clinical translation challenges for this innovative neonatal brain injury treatment.

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Area of Science:

  • Neonatal medicine
  • Neuroscience
  • Regenerative medicine

Background:

  • Neonatal brain injury, including intraventricular hemorrhage and hypoxic-ischemic encephalopathy, is a leading cause of mortality and long-term disability in newborns.
  • Current neonatal intensive care medicine has limitations in fully addressing these devastating conditions.

Purpose of the Study:

  • To review recent advancements in stem cell therapy for neonatal brain injury.
  • To focus on preclinical data and identify key considerations for translating these findings into clinical trials.

Main Methods:

  • Comprehensive review of preclinical studies on stem cell therapy for neonatal brain injury.
  • Analysis of critical factors for clinical translation: cell type, delivery route, dosage, and timing.

Main Results:

  • Stem cell therapy is emerging as a promising therapeutic strategy for neonatal brain injury.
  • Preclinical data highlight the potential efficacy of various stem cell types.

Conclusions:

  • Further research and careful planning are essential for the successful clinical translation of stem cell therapy for neonatal brain injury.
  • Optimizing cell type, delivery, dose, and timing are crucial for future clinical trials.