Related Experiment Video
Updated: Mar 20, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
MLX Is a Transcriptional Repressor of the Mammalian Golgi Stress Response
Mai Taniguchi1, Kanae Sasaki-Osugi, Masaya Oku
1Department of Molecular Biochemistry, Graduate School of Life Science, University of Hyogo.
Abstract:
The Golgi stress response is a homeostatic mechanism that controls the capacity of the Golgi apparatus in accordance with cellular demands. When the capacity of the Golgi apparatus becomes insufficient (Golgi stress), transcription levels of Golgi-related genes encoding glycosylation enzymes, a Golgi structural protein, and components of vesicular transport are upregulated through a common cis-acting enhancer-the Golgi apparatus stress response element (GASE). Here, we identified the transcription factor MLX as a GASE-binding protein. MLX resides in the cytoplasm and does not bind to GASE in normal growth conditions, whereas MLX translocates into the nucleus and specifically binds to GASE in response to Golgi stress. Suppression of MLX expression increased transcriptional induction of target genes of the Golgi stress response, whereas overexpression of MLX reduced GASE-binding of TFE3 as well as transcriptional induction from GASE, suggesting that MLX is a transcriptional repressor of the mammalian Golgi stress response.
Related Concept Videos
Stringent Response in E. coli
Regulation of the Unfolded Protein Response
Master Transcription Regulators
Master Transcription Regulators
Transcriptional Regulation: Riboswitches
Other Stress Responses in Bacteria

