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Related Experiment Video

Updated: Mar 20, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Algodystrophy: complex regional pain syndrome and incomplete forms.

Stefano Giannotti1, Vanna Bottai1, Giacomo Dell'Osso1

  • 1II Orthopaedic and Traumatologic Clinic, University of Pisa, Pisa, Italy.

Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
|June 3, 2016
PubMed
Summary

Complex Regional Pain Syndrome (CRPS), or algodystrophy, presents with pain, swelling, and sensory changes. Incomplete forms may be self-limiting and distinct from CRPS, requiring careful clinical evaluation for accurate diagnosis.

Keywords:
CRPSalgodystrophybone marrow edemacomplex regional pain syndrome

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Area of Science:

  • Pain Medicine
  • Neurology
  • Rheumatology

Background:

  • Complex Regional Pain Syndrome (CRPS), also known as algodystrophy, is a clinical diagnosis characterized by erythema, edema, functional impairment, and sensory/vasomotor disturbances.
  • Current diagnostic approaches for CRPS rely on clinical signs and symptoms, often involving exclusion of other chronic pain conditions.
  • Bone marrow edema syndrome shares similarities but lacks a history of trauma and specific dystrophic skin/vasomotor changes.

Purpose of the Study:

  • To differentiate between CRPS and similar chronic pain conditions like bone marrow edema syndrome.
  • To investigate the potential role of incomplete CRPS forms in unexplained painful conditions.
  • To highlight the importance of clinical evaluation in diagnosing CRPS and related syndromes.

Main Methods:

  • Clinical evaluation of patients presenting with symptoms suggestive of CRPS.
  • Differential diagnosis based on established clinical criteria and exclusion of other pathologies.
  • Review of literature regarding the classification and management of CRPS and related syndromes.

Main Results:

  • Incomplete forms of CRPS, such as bone marrow edema syndrome, may be self-limiting and not require surgical intervention.
  • The distinction between self-limiting syndromes and incomplete CRPS variants remains a subject of debate.
  • Algodystrophy, particularly its incomplete presentations, may be an underlying cause of various unexplained painful conditions like frozen shoulder or painful knee prosthesis.

Conclusions:

  • Accurate diagnosis of CRPS and related syndromes necessitates thorough clinical assessment and consideration of differential diagnoses.
  • Incomplete CRPS variants warrant further investigation to clarify their relationship with established CRPS.
  • Recognizing algodystrophy in its various forms is crucial for managing unexplained chronic pain.