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Updated: Mar 20, 2026
08:16
High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
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Symmetrical peripheral gangrene caused by septic shock
Keisuke Shimbo1, Kazunori Yokota1, Junpei Miyamoto1
1Department of Plastic Surgery, Hiroshima University Hospital, Hiroshima, Japan.
Case Reports in Plastic Surgery & Hand Surgery
|June 3, 2016
Summary
Sepsis survivors with symmetrical peripheral gangrene (SPG) often need amputation. This study details a surgical approach using flaps to preserve extremity length in SPG cases, improving outcomes for patients with limb-threatening conditions.
Area of Science:
- Medicine
- Surgery
- Critical Care Medicine
Background:
- Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection.
- Sepsis can lead to severe complications, including symmetrical peripheral gangrene (SPG), a condition characterized by tissue death in the extremities.
- SPG in sepsis survivors frequently necessitates amputation, significantly impacting patient quality of life.
Observation:
- Three cases of SPG secondary to septic shock were observed.
- Affected patients presented with critical limb ischemia and tissue necrosis.
- The need for limb-saving interventions was identified.
Findings:
- A surgical amputation technique was employed to manage the gangrenous extremities.
- Flap coverage was utilized to reconstruct the amputated digits and peripheral extremities.
- This approach aimed to preserve the length and function of thumbs and fingers.
Implications:
- Surgical amputation combined with flap reconstruction offers a viable strategy for limb salvage in SPG patients.
- This method can potentially reduce the extent of amputation and improve functional outcomes.
- Further research into optimizing surgical techniques for SPG management is warranted.
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