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Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore
Xiao-Dong Zhang1,2, Huasen Wang3, Alexander L Antaris1
1Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Advanced Materials (Deerfield Beach, Fla.)
|June 3, 2016
Abstract:
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.
