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Related Experiment Video

Updated: Mar 20, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Acute Disseminated Encephalomyelitis.

Matthew Philip Gray¹, Marc H Gorelick

¹Assistant Professor of Pediatrics (Gray) and Professor of Pediatrics (Gorelick), Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.

Pediatric Emergency Care

|June 3, 2016

Summary

This summary is machine-generated.

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated pediatric disease causing demyelination and neurological symptoms after infection or vaccination. This review covers ADEM's causes, diagnosis, imaging, and treatment strategies.

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Area of Science:

Neurology
Immunology
Pediatrics

Background:

Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated neurological disorder.
It primarily affects children and is characterized by widespread demyelination in the central nervous system.
ADEM often follows a viral infection or immunization.

Observation:

Patients present with acute-onset, multifocal neurological deficits.
Symptoms can include encephalopathy, seizures, and focal neurological signs.
The clinical presentation is diverse and can mimic other neurological conditions.

Findings:

Diagnostic criteria involve clinical presentation, laboratory findings, and characteristic magnetic resonance imaging (MRI) findings.
MRI typically shows bilateral, asymmetric, large white matter lesions.
Pathophysiology involves autoimmune attack on myelin antigens.

Implications:

Early diagnosis and appropriate management are crucial for improving outcomes in ADEM.
Understanding the pathophysiology aids in developing targeted therapies.
This review provides a comprehensive overview for clinicians managing pediatric neurological emergencies.