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Updated: Mar 20, 2026
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV
Sasirekha Ramani1, Nora Mamani, Rodolfo Villena
1From the *Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas; †Faculty of Medicine, Microbiology and Mycology Program, Institute of Biomedical Sciences; ‡Faculty of Medicine, Department of Pediatrics, Exequiel González Cortes Hospital, Universidad de Chile, Santiago, Chile; §Bill & Melinda Gates Foundation, Seattle, WA; ¶Fred Hutchinson Cancer Research Center, Seattle, Washington; and ‖Global Research in Infectious Diseases, Rio de Janeiro, Brazil.
Background:
Vaccine schedules including bivalent oral and inactivated poliovirus vaccines will replace trivalent oral poliovirus vaccines in 2016.
Methods:
We evaluated rotavirus immunoglobulin A seroresponses when the second dose of Rotarix at 16 weeks was given concomitantly with inactivated or bivalent oral poliovirus vaccines.
Results:
Rotavirus immunoglobulin A seroresponse rate at week 28 was 15% lower in recipients of bivalent oral poliovirus vaccines compared with inactivated poliovirus vaccines.
Conclusion:
Bivalent oral poliovirus vaccine decreases rotavirus IgA seroresponse rates when coadministered at 16 weeks of age.
