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Special considerations in pregnant systemic sclerosis patients
Vincent Sobanski1,2,3,4, David Launay1,2,3,4, Sandrine Depret5
1a U995 Lille Inflammation Research International Center , Univ. Lille , Lille , France.
Expert Review of Clinical Immunology
|June 3, 2016
Summary
Systemic sclerosis (SSc) in women increases risks for premature birth and intrauterine growth restriction, but not miscarriage. Early counseling and folic acid are recommended for SSc patients planning pregnancy.
Area of Science:
- Rheumatology
- Obstetrics & Gynecology
- Reproductive Medicine
Background:
- Systemic sclerosis (SSc) presents unique challenges in evaluating fertility and pregnancy outcomes.
- Existing studies are limited and may have methodological biases.
Purpose of the Study:
- To comprehensively review the literature on the impact of SSc on pregnancy outcomes.
- To examine the effects of pregnancy on women with SSc.
- To summarize physiological changes during pregnancy in SSc patients.
Main Methods:
- Comprehensive literature review.
- Analysis of physiological changes during pregnancy.
- Expert commentary on clinical implications.
Main Results:
- The miscarriage rate in SSc women does not appear to be increased compared to the general population.
- SSc women face a higher risk of premature birth and intrauterine growth restriction.
- Early diffuse cutaneous SSc and corticosteroid use are identified as risk factors for adverse outcomes.
- Folic acid supplementation is associated with prevention of premature birth.
Conclusions:
- Preconception counseling is crucial for all SSc women desiring pregnancy.
- Physiological changes during pregnancy can exacerbate existing organ limitations in SSc patients.
- Management requires careful consideration of SSc-specific risks and benefits.
Keywords:
Systemic sclerosisconnective tissue diseasehypertensionmiscarriageplacentapreeclampsiapregnancyprematurityrenal crisissclerodermaMore Related Videos
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