Surgical Outcomes of Synchronous Multiple Primary Non-Small Cell Lung Cancers

Area of Science:

• Oncology
• Thoracic Surgery
• Cancer Research

Background:

• Prognostic indicators for synchronous multiple primary non-small cell lung cancer (NSCLC) lack consistent definition.
• Identifying reliable prognostic factors is crucial for effective patient management.

Purpose of the Study:

• To analyze prognostic factors in a large cohort of patients with synchronous multiple primary NSCLC.
• To identify independent predictors of survival for improved postoperative management.

Main Methods:

• Retrospective analysis of 285 patients with synchronous multiple primary NSCLC who underwent radical surgical resection.
• Kaplan-Meier method for survival analysis and Cox proportional hazards regression for risk factor evaluation.

Main Results:

• The 5-year disease-free survival (DFS) and overall survival (OS) rates were 58.7% and 77.6%, respectively.
• Multivariate analysis identified male gender, symptomatic disease, and lymph node involvement as independent adverse prognosticators for OS.
• For multiple adenocarcinomas, subtypes other than lepidic predominant and lymph node involvement were unfavorable prognosticators.

Conclusions:

• Male gender, symptomatic disease, and lymph node involvement are significant independent adverse prognosticators in synchronous multiple primary NSCLC.
• Histological subtypes and lymph node status are critical for predicting outcomes in multiple adenocarcinomas.
• These findings offer valuable insights for tailoring postoperative management strategies.