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Autoimmune hepatitis and long-term disease course in children in Turkey, a single-center experience

Miray Karakoyun1, Cigdem O Ecevit, Erhan Kilicoglu

  • 1aDepartment of Pediatric Gastroenterology, Hepatalogy and Nutrition, Gaziantep Children's Hospital, Gaziantep bDepartment of Pediatric Gastroenterology, Hepatology and Nutrition cDepartment of Pediatrics, Dr. Behcet Uz Children's Hospital dDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University, Izmir, Turkey.

European Journal of Gastroenterology & Hepatology
|June 3, 2016
PubMed

Insights

Autoimmune hepatitis (AIH) in Turkish children is predominantly type 1, with most responding well to prednisolone. Long-term treatment with low-dose corticosteroids and azathioprine shows a low relapse rate and manageable side effects.

Area of Science:

  • Pediatric Hepatology
  • Autoimmune Diseases
  • Clinical Immunology

Background:

  • Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology.
  • Pediatric AIH presents with diverse clinical and laboratory features.
  • Understanding regional variations in AIH is crucial for effective management.

Purpose of the Study:

  • To characterize clinic and laboratory features of pediatric AIH in Turkey.
  • To evaluate treatment protocols and responses in children with AIH.
  • To assess long-term follow-up, relapse rates, and side effects of AIH treatment.

Main Methods:

  • Retrospective analysis of 47 children diagnosed with AIH between 1998 and 2012.
  • Data collected included clinical presentation, autoantibody profiles, treatment regimens, and outcomes.
  • Statistical analysis of clinical, laboratory, and treatment data.

Main Results:

  • AIH type 1 was most prevalent (85.1%) in children, typically presenting in the second decade of life.
  • Prednisolone induced complete remission in 86.4% of patients.
  • Combination therapy with low-dose steroids and thiopurine resulted in a low relapse rate (9.4%) and minimal treatment side effects.

Conclusions:

  • Autoimmune hepatitis type 1 is the predominant form in Turkish children.
  • Low-dose corticosteroids combined with azathioprine represent an effective maintenance therapy for pediatric AIH.
  • Long-term management can achieve sustained remission with acceptable safety profiles.
Abstract

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