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Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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[Asthma-COPD overlap syndrome (ACOS)].

Hiroto Takiguchi, Koichiro Asano

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |June 4, 2016
    PubMed
    Summary

    Asthma-COPD overlap syndrome (ACOS) presents challenges in diagnosis and treatment, often seen in elderly patients and smokers. Identifying ACOS patients who benefit from inhaled corticosteroids is crucial for effective management.

    Area of Science:

    • Pulmonology
    • Respiratory Medicine
    • Clinical Science

    Context:

    • Asthma and COPD are distinct diseases but often overlap, particularly in elderly individuals and smokers.
    • The 2014 GINA/GOLD joint document introduced Asthma-COPD Overlap Syndrome (ACOS) to describe patients with features of both conditions.
    • Current evidence for definitive ACOS diagnosis and treatment strategies remains limited.

    Purpose:

    • To highlight the clinical entity of Asthma-COPD Overlap Syndrome (ACOS).
    • To discuss the various phenotypes within ACOS, including severe asthma with airway remodeling and eosinophilic COPD.
    • To emphasize the importance of identifying ACOS patients who respond to inhaled corticosteroids.

    Summary:

    • ACOS is characterized by irreversible airflow limitation and overlapping clinical features of asthma and COPD.

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  • Phenotypes of ACOS include severe asthma with airway remodeling and eosinophilic COPD.
  • Identifying patients who respond to inhaled corticosteroids is a key therapeutic consideration for ACOS.

    • Impact:

    • Improved understanding of complex respiratory conditions like ACOS.
    • Potential for more targeted and effective treatment strategies for patients with overlapping asthma and COPD symptoms.
    • Facilitates further research into the diagnosis and management of ACOS.