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A novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells
1Clare Hall Laboratories, Imperial Cancer Research Fund, South Mimms, Hertfordshire, United Kingdom.
Molecular and Cellular Biology
|April 1, 1989
Abstract:
Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication.