Related Experiment Video

Updated: Mar 20, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.3K

Dynamic CT myocardial perfusion imaging identifies early perfusion abnormalities in diabetes and hypertension:

Rozemarijn Vliegenthart1, Carlo N De Cecco2, Julian L Wichmann3

  • 1Medical University of South Carolina, Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, 25 Courtenay Drive, Charleston, SC, 29425, USA; University of Groningen, University Medical Center Groningen, Center for Medical Imaging-North East Netherlands, Department of Radiology, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Journal of Cardiovascular Computed Tomography
|June 4, 2016
PubMed

Insights

Dynamic computed tomography perfusion imaging (CTPI) reveals early myocardial perfusion reduction in patients with hypertension and diabetes. These findings suggest CTPI can aid in risk stratification for coronary artery disease (CAD).

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Medical Diagnostics

Background:

  • Establishing reference values for myocardial perfusion is crucial for detecting early signs of reduction.
  • Dynamic computed tomography perfusion imaging (CTPI) offers a potential method for assessing myocardial perfusion.

Purpose of the Study:

  • To analyze perfusion parameters from dynamic CTPI in patients with suspected coronary artery disease (CAD).
  • To investigate the relationship between these perfusion parameters and common cardiovascular risk factors.

Main Methods:

  • A multicenter study utilized second-generation dual-source CT for coronary CT angiography (cCTA) and dynamic CTPI.
  • 98 patients suspected of CAD were included, excluding those with visual perfusion defects or prior interventions.
  • Global left ventricular myocardial blood flow (MBF), myocardial blood volume (MBV), and volume transfer constant (K(trans)) were calculated.

Main Results:

  • No significant differences in perfusion parameters were observed based on gender or age.
  • Hypertension and diabetes mellitus were associated with significantly lower MBV and K(trans) (hypertension) and lower MBF and MBV (diabetes).
  • Hyperlipidemia showed a trend towards higher MBF, while smoking and family history did not impact perfusion parameters.

Conclusions:

  • Dynamic CTPI effectively identifies early perfusion disturbances associated with conditions like diabetes and hypertension.
  • Standardization of absolute perfusion measures derived from CTPI could enhance risk stratification for CAD in patients without apparent perfusion defects.
Abstract

Keywords:
Cardiovascular risk factorsComputed tomographyDynamic perfusionMyocardial blood flowMyocardial perfusion imaging

More Related Videos

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

4.1K
Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

2.2K

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
502
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
389
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
727