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Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension

Xue-Song Li1, Hui He1, Yi-Lin Zhao2

  • 1Department of Orthopedics, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|June 4, 2016
PubMed

Insights

Hypertension is linked to lower bone mineral density (BMD) and increased arterial stiffness in men. Reduced femoral neck BMD may independently contribute to elevated brachial-ankle pulse wave velocity (baPWV) in hypertensive individuals.

Area of Science:

  • Cardiovascular Medicine
  • Bone Metabolism
  • Hypertension Research

Background:

  • Hypertension (HTN) and osteoporosis are known contributors to atherosclerosis.
  • Limited research exists on the link between arterial stiffness and bone mineral density (BMD) specifically in men with HTN.

Purpose of the Study:

  • To investigate the relationship between arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), and BMD in men with and without hypertension.

Main Methods:

  • Cross-sectional study involving 355 men with HTN and 353 controls.
  • Measurements included brachial-ankle pulse wave velocity (baPWV) and bone mineral density (BMD), particularly at the femoral neck (FN).

Main Results:

  • Patients with HTN exhibited significantly lower femoral neck BMD (0.662±0.195 g/cm² vs. 0.713±0.204 g/cm², P=.001) and higher baPWV (1403.3±156.8 cm/s vs. 1354.8±136.0 cm/s, P<.001) compared to controls.
  • Multiple linear regression revealed a negative association between FN BMD and baPWV in the hypertensive group.

Conclusions:

  • Hypertension is associated with reduced BMD and increased arterial stiffness.
  • Lower femoral neck BMD may be an independent risk factor for elevated arterial stiffness in men with hypertension.

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