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Diabetes is associated with perforated appendicitis: evidence from a population-based study
Po-Li Wei1, Herng-Ching Lin2, Li-Ting Kao3
1Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Cancer Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
Patients with diabetes have a higher risk of perforated appendicitis. This study found that diabetes significantly increases the likelihood of appendicitis perforation, highlighting its importance in patient outcomes.
Area of Science:
- Medical research
- Epidemiology
- Public health
Background:
- Appendicitis is a common surgical emergency.
- Perforated appendicitis is associated with increased morbidity and mortality.
- The role of diabetes in appendicitis outcomes requires further investigation.
Purpose of the Study:
- To examine the association between diabetes and perforated appendicitis.
- To determine if diabetes influences the risk of appendicitis perforation.
- To analyze population-based data for insights into this relationship.
Main Methods:
- Utilized the Longitudinal Health Insurance Database 2005 from Taiwan.
- Included 4,806 patients hospitalized for acute appendicitis.
- Employed conditional logistic regression to assess the odds ratio of perforation in diabetic patients.
Main Results:
- Perforated appendicitis rates were 46.2% in diabetic patients versus 28.3% in non-diabetic patients.
- A significant difference (P < .001) in perforation rates was observed between the groups.
- Diabetic patients had an adjusted odds ratio of 1.35 (95% CI: 1.11-1.65) for perforated appendicitis.
Conclusions:
- Diabetes is a significant risk factor for perforated appendicitis.
- Diabetic patients experience a higher incidence of appendicitis perforation.
- These findings underscore the importance of considering diabetes status in managing appendicitis.
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