Related Experiment Video
Updated: Mar 20, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Depression Symptoms in Chronic Left Hemisphere Stroke Are Related to Dorsolateral Prefrontal Cortex Damage
Kristopher Grajny1, Harshini Pyata1, Katherine Spiegel1
1From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
Abstract:
Damage to the brain's mood regulation systems may contribute to poststroke depression. This study examines relationships between depression symptoms and psychosocial factors and then uses multivariate lesion-symptom mapping to localize depression symptoms in people with chronic left hemisphere stroke. Depression symptoms relate inversely to education and directly to physical disability. Damage in the left dorsolateral prefrontal cortex is associated with greater depression symptoms. These results demonstrate a neurological contribution to depression symptoms in chronic left hemisphere stroke and provide evidence of convergent biological mechanisms for poststroke depression symptoms and major depression with regard to left dorsolateral prefrontal cortex dysfunction.
More Related Videos
Related Concept Videos
Lateralization
Role of Cerebellum and Prefrontal Cortex in Memory
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Cerebral Hemispheres
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

