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[Expression and clinical significance of CD147 in parathyroid carcinoma]
1Department of Pathology, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038, China.
Objective:
To study the expression and clinical significance of CD147 in the patients of parathyroid carcinoma.
Methods:
Fourteen cases of parathyroid carcinoma encountered during the period from 2012 to 2015 were enrolled. Thirty three cases of parathyroid adenoma encountered during the same period were enrolled. The expression of CD147 in parathyroid carcinoma and parathyroid adenoma was studied by means of immunohistochemistry (EnVision method).
Results:
CD147 positive color was brown and yellow, and positive position was located mainly in the cytomembrane, and a small amount of cytoplasm was appeared. Among 14 cases of parathyroid carcinoma, 11 cases of CD147 positive score was 3+ , 3 cases of CD147 positive score was 2+ ; Among 33 cases of parathyroid adenoma , 8 cases of CD147 positive score was 2+ , 15 cases of it was 1+ , 10 cases of it was negative. CD147 was highly expressed in parathyroid carcinoma tissues, and the expression of CD147 was significantly different from the expression of parathyroid adenoma(P<0.05).
Conclusion:
CD147 immunohistochemical staining can help to diagnose parathyroid carcinoma.
