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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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DNA Methylation in Cancer and Aging

Michael Klutstein1, Deborah Nejman1, Razi Greenfield1

  • 1Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.

Cancer Research
|June 4, 2016
PubMed
Summary

DNA methylation abnormalities are common in cancer but poorly understood. This review explores how DNA methylation patterns form, how they prevent gene activation, and their programmed role in aging-related cancer development.

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