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Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

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Published on: May 17, 2024

Massive exophytic malignant peripheral nerve sheath tumor.

Derek Khorsand¹, Jack Porrino¹, Erin Flaherty¹

¹Department of Radiology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.

Radiology Case Reports

|June 4, 2016

Summary

A rare, massive malignant peripheral nerve sheath tumor developed from a shoulder neurofibroma. This case highlights unusual tumor growth and provides imaging and pathology comparisons.

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An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Area of Science:

Oncology
Radiology
Pathology

Background:

Neurofibromas are benign nerve tumors, typically small.
Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive.

Observation:

A 69-year-old man presented with a solitary neurofibroma on his right posterior shoulder.
The neurofibroma had degenerated into a massive MPNST, significantly exceeding average reported sizes.

Findings:

Detailed comparison of radiographic, MRI, and CT features with gross appearance and histopathology.
Analysis of imaging characteristics of an exceptionally large MPNST.

Implications:

This case expands understanding of MPNST growth potential.
Highlights the importance of vigilant monitoring of neurofibromas for malignant transformation.
Provides valuable data for diagnostic imaging and surgical planning of large MPNSTs.