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Association between Asthma and Autism Spectrum Disorder: A Meta-Analysis
Zhen Zheng1,2, Li Zhang1,2, Tingting Zhu1,2
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Plos One
|June 4, 2016
Summary
This meta-analysis found no significant association between asthma and autism spectrum disorder (ASD). Further research is needed to confirm these findings on asthma and ASD.
Area of Science:
- Epidemiology
- Public Health
- Pediatrics
Background:
- Asthma and autism spectrum disorder (ASD) are common childhood conditions.
- Previous studies have yielded conflicting results regarding a potential association between asthma and ASD.
Purpose of the Study:
- To conduct a meta-analysis summarizing epidemiological evidence on the association between asthma and autism spectrum disorder (ASD).
Main Methods:
- Systematic literature search of PubMed, Embase, and Cochrane Library up to February 2016.
- Inclusion of observational studies investigating the asthma-ASD link.
- Random effects modeling for pooled risk estimates, with subgroup analysis and publication bias assessment.
Main Results:
- Ten studies with 175,406 participants (8,809 with ASD) were analyzed.
- Cross-sectional studies showed a higher asthma prevalence in ASD (20.4% vs. 15.4%), but the pooled OR was not statistically significant (1.26, P=0.07).
- Case-control studies found no evidence of association (OR 0.98, P=0.94), with no significant publication bias detected.
Conclusions:
- Current meta-analysis does not support an association between asthma and autism spectrum disorder.
- Further prospective studies are recommended to definitively ascertain the relationship between asthma and ASD.
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