Related Experiment Video
Updated: Mar 20, 2026

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
Published on: November 10, 2023
Obstructive Fibrinous Tracheal Pseudomembrane
Yoann Ammar1, Juliette Vella-Boucaud, Claire Launois
1From the Department of Respiratory Diseases, University Hospital, Reims, France.
Abstract:
Obstructive fibrinous tracheal pseudomembrane (OFTP) is a rare and potentially severe complication of endotracheal intubation characterized by a tubular pseudomembrane that obstructs the trachea and induces clinical symptoms of airway obstruction after extubation. In this report, we reviewed and summarized all published cases of OFTP (n = 58) between 1981 and 2015. Twenty-three of 52 patients were men, and the mean age was 36 ± 22 years. Intubation was emergent in 41 of 53 cases. OFTP was revealed by acute symptoms in 19 of 39 cases and led to acute respiratory failure in 13 of 39 cases. Symptoms occurred 3 ± 3 days after extubation. A tracheal obstruction ≥70% was observed in 14 of 18 cases. Bronchoscopic removal was performed in 49 of 58 cases with no recurrence. In conclusion, OFTP is characterized by a typical clinical and endoscopic presentation, with no recurrence after bronchoscopic removal. Early recognition and bronchoscopy are key elements for efficient diagnosis and treatment.
Insights
Obstructive fibrinous tracheal pseudomembrane (OFTP) is a rare complication after endotracheal intubation. Early recognition and bronchoscopic removal are crucial for effective treatment and preventing recurrence.
Area of Science:
- Pulmonology
- Critical Care Medicine
- Otolaryngology
Background:
- Obstructive fibrinous tracheal pseudomembrane (OFTP) is a rare but severe complication following endotracheal intubation.
- It presents as a tubular pseudomembrane obstructing the trachea, leading to airway obstruction symptoms post-extubation.
Purpose of the Study:
- To review and summarize all published cases of OFTP.
- To analyze the clinical presentation, diagnosis, and treatment outcomes of OFTP.
Main Methods:
- Systematic review of published literature on OFTP cases from 1981 to 2015.
- Analysis of patient demographics, intubation details, symptom onset, severity of obstruction, and treatment interventions.
Main Results:
- 58 cases of OFTP were identified. The mean age was 36 ± 22 years, with 23/52 males. Emergent intubation was common (41/53 cases).
- Symptoms appeared 3 ± 3 days post-extubation, with 19/39 cases presenting acutely. Significant tracheal obstruction (≥70%) was noted in 14/18 cases. Acute respiratory failure occurred in 13/39 cases.
- Bronchoscopic removal was performed in 49/58 cases, with no reported recurrences.
Conclusions:
- OFTP has a characteristic clinical and endoscopic presentation.
- Early recognition and bronchoscopic intervention are vital for successful diagnosis and treatment, with no recurrence observed after this procedure.
Related Concept Videos
Trachea
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
The Bronchial Tree
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
Tracheostomy: Procedure and Tubes
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Anatomy of Respiratory System II: Lower Respiratory Tract
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...

