Related Experiment Video
Updated: Mar 20, 2026
06:47
Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
7.5K
Sorbicillinoids from Fungi and Their Bioactivities
Jiajia Meng1, Xiaohan Wang2, Dan Xu3
1Key Laboratory of Plant Pathology, Ministry of Agriculture/Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China. mengjiajiax@163.com.
Molecules (Basel, Switzerland)
|June 4, 2016
Summary
Sorbicillinoids are fungal metabolites with diverse biological activities. This review summarizes their occurrence, structures, and potential as pharmaceutical and agrochemical agents.
Area of Science:
- Natural Products Chemistry
- Mycology
- Medicinal Chemistry
Background:
- Sorbicillinoids are hexaketide metabolites produced by fungi.
- These compounds exhibit significant cytotoxic, antioxidant, antiviral, and antimicrobial properties.
- Over 90 sorbicillinoids have been identified to date.
Purpose of the Study:
- To review the occurrence and structures of sorbicillinoids.
- To summarize the known biological activities of sorbicillinoids.
- To highlight their potential in pharmaceutical and agrochemical development.
Main Methods:
- Literature review of scientific databases.
- Analysis of reported sorbicillinoid structures.
- Compilation of data on biological activities.
Main Results:
- Sorbicillinoids are structurally diverse fungal metabolites.
- A wide range of biological activities have been documented.
- Their unique structures offer opportunities for drug discovery.
Conclusions:
- Sorbicillinoids represent a promising class of natural products.
- Further research into their synthesis and bioactivity is warranted.
- Potential applications in medicine and agriculture exist.
Related Concept Videos
01:15Antifungal Agents
1
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
1
01:29Overview of Fungi
2.3K
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
2.3K
01:27Production of Antibiotics
5
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
5
01:29Fungal Group Zygomycota
2.0K
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.0K
01:23Inhibitors of Gram-positive Cell Wall Synthesis
8
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
8
01:27Combined Effects of Drugs: Synergism
7.2K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
7.2K