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Most systematic reviews of adverse effects did not include unpublished data
Su Golder1, Yoon K Loke2, Kath Wright3
1Department of Health Sciences, University of York, Heslington, York YO10 5DD, UK.
Journal of Clinical Epidemiology
|June 5, 2016
Summary
Most systematic reviews on adverse effects do not search for unpublished data. However, nearly half of those that do successfully identify and include this crucial information, improving review comprehensiveness.
Area of Science:
- Medical Research
- Evidence Synthesis
- Pharmacovigilance
Background:
- Systematic reviews are crucial for synthesizing research findings.
- Identifying unpublished data is vital for comprehensive systematic reviews, especially for adverse effects.
- Previous literature suggests a gap in the search for unpublished data in systematic reviews.
Purpose of the Study:
- To determine the proportion of systematic reviews on adverse effects that search for unpublished data.
- To assess the success rate of identifying unpublished data for inclusion in systematic reviews.
Main Methods:
- Systematic search of the Database of Abstracts of Reviews of Effects (DARE) for reviews published in 2014.
- Independent screening by two reviewers to identify reviews evaluating adverse effects.
- Data extraction on search strategies, inclusion of unpublished studies, and sources of unpublished data.
Main Results:
- Out of 348 eligible systematic reviews, 39% searched for specific sources of unpublished data.
- Of those searching, 48% successfully included unpublished data.
- Overall, 22% of systematic reviews included unpublished data, regardless of specific search strategies.
Conclusions:
- The majority of systematic reviews on adverse effects do not employ specific strategies to find unpublished data.
- When specific searches for unpublished data are conducted, they are successful in nearly half of cases.
- Improving search strategies for unpublished data can enhance the completeness of adverse effect systematic reviews.
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