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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Mar 20, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Immunotherapy for Lung Cancer.

Niels Reinmuth1, Martin Reck

  • 1Department of Thoracic Oncology, Fachklinik Gauting, Member of the German Center for Lung Research (DZL), Gauting, Germany.

Oncology Research and Treatment
|June 5, 2016
PubMed
Summary
This summary is machine-generated.

Cancer cells evade immune detection, a major hurdle in treatment. New immunotherapies targeting immune checkpoints show promise for improving lung cancer survival by restoring antitumor immune responses.

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Area of Science:

  • Oncology
  • Immunology

Background:

  • Immune evasion is a critical mechanism for cancer survival and progression.
  • Restoring antitumor immune responses is a key research area for cancer treatment.

Purpose of the Study:

  • To investigate the potential of immune checkpoint inhibitors in improving lung cancer outcomes.
  • To highlight the role of immunotherapies in current and future lung cancer treatment strategies.

Main Methods:

  • Review of current research on immune evasion in cancer.
  • Analysis of clinical data for immunotherapies targeting immune checkpoints (e.g., CTLA-4, PD-1) in lung cancer.
  • Evaluation of the integration of immunotherapies into existing lung cancer treatment protocols.

Main Results:

  • Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1) receptors demonstrate potential in enhancing tumor response and patient survival in lung cancer.
  • Approved immunomodulating agents offer new therapeutic avenues for selected lung cancer patients.

Conclusions:

  • Immunotherapies targeting immune checkpoints represent a significant advancement in lung cancer treatment.
  • The incorporation of immunotherapies into treatment cascades holds high expectations for improving patient outcomes in lung cancer.