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Updated: Jan 2, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer
Ling Yao1, Yayun Chi1, Xin Hu1
1Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.
Background:
BCDIN3D is a member of the Bin3 methyl-transferase family that targets the 5' mono-phosphate of nucleic acids. Although BCDIN3D has been shown to increase tumorigenic phenotypes and invasiveness in MDA-MB-231 cells, its the clinical implications in breast cancer remain unclear.
Methods:
We screened for BCDIN3D using tissue microarrays constructed from 250 patients who were histologically confirmed to have invasive ductal breast carcinoma at the Fudan University Shanghai Cancer Center.
Results:
The survival analysis by Kaplan-Meier and Cox regression showed that BCDIN3D expression level served as a prognostic factor for disease-free survival (P = 0.042). The prognostic value of BCDIN3D was most significant in triple-negative breast cancer (TNBC) patients (P = 0.007).
Conclusions:
BCDIN3D might serve as an important prognostic factor for TNBC patients.
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