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Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
Published on: February 2, 2019
Energetic interventions for healthspan and resiliency with aging
Derek M Huffman1, Marissa J Schafer2, Nathan K LeBrasseur2
1Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Strategies like caloric restriction (CR) and exercise impact aging. While CR extends lifespan, exercise consistently enhances resilience against stressors, crucial for healthspan in aging humans.
Area of Science:
- Gerontology and aging research.
- Stress resilience and longevity.
Background:
- Aging interventions aim to extend lifespan and healthspan.
- Organismal resilience against stressors is vital for maintaining function in old age.
- Conventional rodent housing may not accurately reflect real-world resilience challenges.
Purpose of the Study:
- To evaluate the impact of aging interventions on organismal resilience.
- To understand how different strategies affect healthspan and stress response.
- To highlight the importance of resilience in aging research for human translation.
Main Methods:
- Review of existing studies on behavioral (caloric restriction, exercise) and pharmacological interventions (resveratrol, rapamycin, metformin, senolytics).
- Comparative analysis of intervention effects on longevity, healthspan, and resilience.
- Assessment of resilience against various stressors like infections, surgery, and frailty.
Main Results:
- Caloric restriction (CR) significantly extends lifespan and retards age-related diseases.
- Exercise demonstrates more consistent benefits for organismal resilience against diverse stressors.
- CR can impair responses to infections and healing, despite improving cellular defenses.
Conclusions:
- Interventions impact longevity, healthspan, and resilience differently.
- Organismal robustness is a critical, understudied aspect of aging.
- Understanding resilience is key for translating aging strategies to human health and function.
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