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Updated: Mar 20, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
[Confocal microscopy as an early relapse marker after keratoplasty due to Fusarium solani keratitis]
L Daas1, M Bischoff-Jung2, A Viestenz2
1Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes UKS, Kirrberger Str. 100, Gebäude 22, 66424, Homburg/Saar, Deutschland. loay.daas@uks.eu.
Abstract:
In the case of therapy-resistant keratitis an infection with Fusarium solani should be taken into consideration as a rare but very severe eye disease. In the majority of cases Fusarium solani keratitis will result in a protracted clinical course despite aggressive medicinal and surgical interventions. We describe the case of a referred patient after intensive topical, intracameral and systemic antibacterial and antimycotic therapy as well as surgical treatment with emergency keratoplasty à chaud because of Fusarium solani keratitis. The patient presented to our department with persistent discomfort for further therapeutic interventions. Using confocal microscopy we were able to demonstrate the presence of fungal hyphae in the host cornea and the graft, which was important for making further surgical decisions. Furthermore, this emphasizes the role of confocal microscopy as an early relapse marker during the clinical monitoring.
Insights
Fusarium solani keratitis is a severe eye infection often resistant to treatment. Confocal microscopy can detect fungal hyphae, aiding in early relapse detection for Fusarium keratitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Therapy-resistant keratitis necessitates considering rare but severe infections like Fusarium solani.
- Fusarium solani keratitis typically follows a prolonged course despite aggressive medical and surgical management.
Observation:
- A patient with persistent discomfort after extensive treatment for Fusarium solani keratitis was referred for further intervention.
- Confocal microscopy revealed fungal hyphae in both the host cornea and the corneal graft.
Findings:
- Confocal microscopy confirmed the presence of fungal hyphae, guiding subsequent surgical decisions.
- The study highlights the utility of confocal microscopy in managing Fusarium solani keratitis.
Implications:
- Confocal microscopy serves as a crucial tool for early detection of relapse in Fusarium solani keratitis.
- This case underscores the importance of considering rare fungal infections in severe keratitis cases.
- Advanced imaging techniques like confocal microscopy can improve patient outcomes in complex ocular infections.
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