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High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
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Persisters-as elusive as ever.

Niilo Kaldalu1, Vasili Hauryliuk1,2,3, Tanel Tenson4

  • 1University of Tartu, Institute of Technology, Nooruse 1, 50411, Tartu, Estonia.

Applied Microbiology and Biotechnology
|June 6, 2016
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Summary
This summary is machine-generated.

Bacterial persisters, crucial in infections, are a diverse group of physiological responses. This review emphasizes the need to avoid oversimplifying their mechanisms, urging rigorous validation for each specific case.

Keywords:
Antibiotic developmentAntibiotic resistanceAntibiotic toleranceBacterial infectionsBet hedgingPersisters

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Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Drug Resistance

Background:

  • Persisters are drug-tolerant bacterial subpopulations implicated in recurrent infections.
  • Research has focused on identifying mechanisms of persister formation and eradication strategies.

Purpose of the Study:

  • To highlight the heterogeneity of bacterial persistence.
  • To caution against oversimplification of persister mechanisms.
  • To advocate for rigorous validation of persistence mechanisms in specific contexts.

Main Methods:

  • Literature review and critical analysis of existing research on bacterial persisters.
  • Examination of factors influencing persister phenotypes, including bacterial species, strain, growth conditions, and antibiotics.

Main Results:

  • The term "persistence" currently encompasses a wide range of heterogeneous physiological phenomena.
  • Mechanisms of persistence vary significantly based on experimental conditions and bacterial context.

Conclusions:

  • A unified understanding of bacterial persistence is challenged by its inherent heterogeneity.
  • Oversimplification of persister mechanisms can hinder effective treatment strategies.
  • Future research must rigorously validate the applicability of proposed mechanisms to specific bacterial species and conditions.